Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity
نویسندگان
چکیده
منابع مشابه
Endoplasmic Reticulum Stress and Pancreatic Cancer
Endoplazmik retikulum (ER) stres, farklı uyaranlar sonucu gelişen önemli hücresel bir olaydır. ER strese farklı yanıt türleri vardır. Bunlardan biri evrimsel olarak korunmuş katlanmamış protein cevabıdır (UPR). UPR’nin moleküllerin sonraki aktivasyonu için üç sensörü vardır. Bu sensörler inozitol gerektiren enzim 1 (IRE1), aktive edici transkripsiyon faktörü 6 (ATF6) ve protein kinaz RNA (PKR)-...
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Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
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endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...
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Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
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Lipotoxicity-induced mesangial cell apoptosis is implicated in the exacerbation of diabetic nephropathy (DN). Protein arginine methyltransferases (PRMTs) have been known to regulate a variety of biological functions. Recently, it was reported that PRMT1 expression is increased in proximal tubule cells under diabetic conditions. However, their roles in mesangial cells remain unexplored. Thus, we...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2018
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-018-0893-2